About 6 results found for searched term "Squalene synthase" (0.301 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42952 | Squalene synthase-IN-1 | Others |
| Squalene synthase-IN-1 is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. | ||
| M8867 | Zaragozic acid A trisodium salt | Squalene synthase |
| Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. | ||
| M28612 | BPH-652 | Others |
| BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation). | ||
| M28935 | YM-53601 free base | Farnesyl Transferase |
| YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M28936 | YM-53601 | Farnesyl Transferase |
| YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M28996 | Lapaquistat acetate | Others |
| TAK-475 | ||
| Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway. Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research. | ||
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